Title page for etd-1208111-163255


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URN etd-1208111-163255
Author Bo-wei Chen
Author's Email Address No Public.
Statistics This thesis had been viewed 5564 times. Download 186 times.
Department Marine Biotechnology and Resources
Year 2011
Semester 1
Degree Ph.D.
Type of Document
Language English
Title Eunicellin-Based Diterpenoids from the Soft Corals of Cultured Klyxum simplex and Wild-Type Cladiella hirsuta and Their Bioactivities
Date of Defense 2011-10-05
Page Count 468
Keyword
  • simplex
  • hirsute
  • eunicellin
  • diterpenoid
  • Abstract In order to discover new bioactive compounds, the chemical constituents from the organic extracts of the cultured soft coral Klyxum simplex and wild-type soft coral Cladiella hirsute were studied. 27 new eunicellin-based
    diterpenoids, klysimplexins A–X (1–24) and klysimplexin sulfoxides A–C (25–27), were isolated from a cultured soft coral Klyxum simplex. Furthermore, eight new eunicellin-base diterpenoids, hirsutalins C (28) and F–L (29–35), were isolated from the soft coral Cladiella hirsuta. The structures of compounds 1–35 were elucidated by spectroscopic methods, in particular 1D and 2D NMR
    experiments. The absolute stereochemistries of 1, 3, 12, and 22 were determined by Mosher’s method. The structure of 1 was further confirmed by a single-crystal X-ray diffraction analysis. The absolute configurations of 1, 3, 12, and 22 were determined by Mosher’s method. Compounds 2, 8, 17, 20, and 29 have been shown to exhibit cytotoxicity toward a limited panel of cancer cell
    lines. Compounds 10–14, 18, 19, 25–28, and 31 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compounds
    18, 19, and 27 also could effectively reduce the level of the COX-2 protein.
    Advisory Committee
  • Yang-Chang Wu - chair
  • Sung Ping-Jyun - co-chair
  • Fang-Rong Chang - co-chair
  • Sheng-yang Wang - co-chair
  • Jyh-Horng Sheu - advisor
  • Files
  • etd-1208111-163255.pdf
  • Indicate in-campus at 5 year and off-campus access at 5 year.
    Date of Submission 2011-12-08

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