Title page for etd-1126114-185803


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URN etd-1126114-185803
Author Yu-Jih Su
Author's Email Address bensu8@gmail.com
Statistics This thesis had been viewed 5581 times. Download 29 times.
Department Biological Sciences
Year 2014
Semester 1
Degree Ph.D.
Type of Document
Language English
Title The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients
Date of Defense 2014-12-18
Page Count 193
Keyword
  • systemic lupus erythematosus
  • antiviral immunity
  • apoptosis
  • disease activity
  • oxidative stress
  • autoantibodies
  • Abstract   Introduction: Apoptosis is one important pathogenesis associated with disease activity in systemic lupus erythematosus (SLE). The inflammation reactions secondary to the underlying autoimmune disease is believed to play an important role in aberrant apoptosis in lupus, and activates inflammatory cell to propagate the immune reaction, and finally, involved the organ damage, and so is the disease activity. Apoptosis is a complex process and may take several hours to develop. Clinical evidence of SLE patients suffers from both defective regeneration and mobilization of circulating endothelial progenitor cells.
      Method: We hypothesize that significantly increased these inflammatory biomarkers, increase leukocyte apoptosis and circulating autoantibodies in SLE patients with disease flare up, and the aberrant viral activation with consumption of intracellular viral receptor is associated elevated lupus disease activity, and we also speculate that immunosuppressant adjuvant treatments can suppress the either inflammation or oxidative stress reaction, decrease leukocyte apoptosis and improve disease activity gradually. Endothelial progenitor cells (EPC) are helping vessel regeneration, but the adhesion molecules are directing inflammatory cells against vessels. Their roles in lupus will be explored in this current study, and the link between it and the disease activity will also be studied.
      Results: Study result showed apoptosis is significantly higher in SLE than disease and normal control, and B cell APO2.7 is positively associated with disease activity. The anti-Ro autoantibody is associated with neuropsychiatric SLE, and neuropsychiatric SLE patients have higher disease activity than non-neuropsychiatric SLE patients. The adhesion molecule ICAM-1 and EPC number are positively associated with disease activity. Another adhesion molecule L-selectin is negatively associated with disease activity. Besides, we noticed that poor immunity to virus is associated with higher disease activity in SLE patients. The caspase-9 level is also negatively associated with disease activity. This study indicates mitochondrial activation is prevalent in active SLE patients. All of these need further investigation.
    Advisory Committee
  • Hsueh-Wen Chang - chair
  • Jian-de Lee - co-chair
  • Chun-lin Chen - co-chair
  • Chung-Jen Chen - co-chair
  • Cheng-Hsien Lu - advisor
  • Files
  • etd-1126114-185803.pdf
  • Indicate in-campus at 5 year and off-campus access at 5 year.
    Date of Submission 2014-12-26

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