Title page for etd-0911112-174722


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URN etd-0911112-174722
Author Mu-Keng Hsieh
Author's Email Address No Public.
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Department Marine Biotechnology and Resources
Year 2012
Semester 1
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Studies on the Secondary Metabolites from the Formosan Soft Coral Sarcophyton ehrenbergi
Date of Defense 2012-08-21
Page Count 235
Keyword
  • anti-HCMV
  • diterpene
  • San-Hsien-Tai
  • cytotoxicity
  • Sarcophyton ehrenbergi
  • Abstract In the course of studying on secondary metabolites from marine organisms, we have investigated the chemical constituents of the soft coral Sarcophyton ehrenbergi collected at San-Hsien-Tai, Taitong County, Taiwan. Chromatographic separation of the organic extracts has led to the isolation of nine new cembrane diterpenes 1–9, and a initial natural separation of known cembrane diterpene 10. The chemical structures of pure compounds were determined by spectral (NMR, MS, UV and IR) and physical data, as well as comparison with the spectroscopic data of related chemicals in literature.
    Moreover, the metabolites 1–10 were evaluated in vitro for their cytotoxicity against of A-549 (human lung epithelial carcinoma), HT-29 (human colon adenocarcinoma), and P-388 (mouse lymphocytic leukemia) cells, as well as anti-HCMV activity. Compounds 3, 6, 9, and 10 were shown to exhibit significant cytotoxicity activities against P-388 with ED50 values of 2.7, 3.6, 2.0, and 3.0 μg/mL, respectively. Compound 1, 2, 3, and 7 exhibited inhibitory activity against anti-HCMV, with EC50 values of 60.0, 46.0, 5.0, and 45.0 μg/mL.
    Advisory Committee
  • Jyh-Horng Sheu - chair
  • Chih-Chuang Liaw - co-chair
  • Fang-Rong Chang - co-chair
  • Ian-Lih Tsai - co-chair
  • Chang-Yih Duh - advisor
  • Files
  • etd-0911112-174722.pdf
  • Indicate in-campus at 99 year and off-campus access at 99 year.
    Date of Submission 2012-09-11

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