Title page for etd-0905108-134315


[Back to Results | New Search]

URN etd-0905108-134315
Author Hsuan-yu Chen
Author's Email Address No Public.
Statistics This thesis had been viewed 5572 times. Download 3 times.
Department Biological Sciences
Year 2007
Semester 2
Degree Master
Type of Document
Language English
Title Prognostic Role of Hepatoma-derived growth factor (HDGF) in Breast Cancer
Date of Defense 2008-07-03
Page Count 53
Keyword
  • HDGF
  • Abstract Purpose: Hepatoma-derived growth factor (HDGF) is a novel growth factor that plays an important role in the pathogenesis and progression of a variety of cancers. The present study was designed to elucidate the role of HDGF expression in breast cancer.
    Patients and Methods: Tissues were collected from patients with breast cancer who underwent surgery. The expression of HDGF, Ki-67, FOXP3, p53, ER, PR and CD4+CD25+ in 71 patients with breast cancer containing a) malignant tissue (n = 58), b) uninvolved breast tissue obtained from tissue distant from the tumor (n = 13) using immunohistochemistry (IHC). The content of CD4+CD25 high in PBMC was determined by flow cytometry. Data were expressed as ROC Curve and the significance of the differences was assessed by ANOVA.
    Results: IHC analysis found that the expression level of HDGF and CD4+CD25high in tumor tissues was significantly higher than that in non-tumor tissues (P < 0.001). Besides, HDGF and CD4+CD25high expression was significantly correlated with tumor grades of breast cancer (P < 0.05). Increased circulating HDGF and CD4+CD25high levels were found in serum from patients with breast cancer compared with serum from healthy controls (P < 0.001). The nuclear HDGF labeling index was positively correlated with Ki-67, FOXP3 and p53 in breast cancer (P < 0.05). Finally, incubation with recombinant HDGF significantly increased the content of CD4(+)CD25high T cells in peripheral blood mononuclear cells (PBMCs).
    Conclusion: The present study demonstrated HDGF overexpression is correlated with tumor grades, recurrence, proliferation, and tumor immunity in breast cancer. In the future, HDGF may constitute a novel molecular target for diagnosis and treatment of breast cancer.
    Advisory Committee
  • Hu Tsung-Hui - chair
  • Yeh Ming-Hsin - co-chair
  • Tai Ming-Hong - advisor
  • Files
  • etd-0905108-134315.pdf
  • indicate in-campus access in a year and off_campus not accessible
    Date of Submission 2008-09-05

    [Back to Results | New Search]


    Browse | Search All Available ETDs

    If you have more questions or technical problems, please contact eThesys