Title page for etd-0901111-205759


[Back to Results | New Search]

URN etd-0901111-205759
Author Yun-Jie Xio
Author's Email Address No Public.
Statistics This thesis had been viewed 5572 times. Download 376 times.
Department Marine Biotechnology and Resources
Year 2010
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Chemical Constituents and Biological Activities of the Formosan Soft Coral Lemnalia philippinensis
Date of Defense 2011-07-14
Page Count 156
Keyword
  • lemnaphilins
  • neolemnane
  • 5-cycloneolemnane
  • eremophliane
  • Lemnalia philippinensis
  • 4
  • lemnaphinolide
  • ylangene
  • Abstract From the chemical investigation of a Formosan soft coral Lemnalia philippinensis, we had discovered seven new sesquiterpenoids, including three ylangene-type sesquiterpenoids lemnaphilins A-C ( 1-3 ), two eremophilane-type sesquiterpenoids lemnaphilins D-E ( 4-5 ), one neolemnane-type sesquiterpenoid lemnaphilin F (6), and one 4,5-cycloneolemnane-type sesquiterpenoid lemnaphinolide (7), along with eight known compounds, lemnalol(8) , 11,12-dihydroxy-6,10-eremopi
    -laiene (9),4(S*)-acetoxy,10(S*)-hydroxy,5-oxo,l(S*),12(S*)neolemna–2(Z), 8–diene
    (10), laevinone A (11), 2-oxolemnacarnol(12), lemnal-1(10)- ene-2,12-dione (13), 2,7
    -nardosinoxanedione (14), elongatol B (15). The structures of these compounds were established by the detailed spectral analysis (IR, MS, 1D, 2D NMR) and by comparison of the spectral data with those of the related known compounds.
    The cytotoxicity of fifteen compounds (1–15) against with three cell lines, including HepG2 (human liver hepatocellular carninoma cells)、MDA-MB231(human breast cancer cells) and A549(human respiratory epithelial cells)was also determined. Only lemnaphilin A exhibited cytotoxicity, with IC50 values 15.99、16.31and 15.81 μg/mL.
    Advisory Committee
  • Fang-Rong Chang - chair
  • Chih-Chuang Liaw - co-chair
  • Jyh-Horng Sheu - advisor
  • Files
  • etd-0901111-205759.pdf
  • Indicate in-campus at 5 year and off-campus access at 5 year.
    Date of Submission 2011-09-01

    [Back to Results | New Search]


    Browse | Search All Available ETDs

    If you have more questions or technical problems, please contact eThesys