Title page for etd-0828112-140112


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URN etd-0828112-140112
Author Yan-ning Lee
Author's Email Address No Public.
Statistics This thesis had been viewed 5567 times. Download 213 times.
Department Marine Biotechnology and Resources
Year 2011
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Continued Study on the Natural Products from the Soft Coral Cladiella krempfi
Date of Defense 2012-07-20
Page Count 161
Keyword
  • Cladiella krempfi
  • eunicellin-based diterpenoids
  • chromatography
  • anti-inflammation
  • krempfielin
  • Abstract Seven new eunicellin-based diterpenoids, krempfielins K-Q (1-7), along with six known compounds, litophynin I (8), krempfielin A (9), krempfielin D (10), sclerophytin F (11), litophynol B (12), and litophynol I monoacetate (13), have been isolated from the soft coral Cladiella krempfi which was collected from Penghu Island of Taiwan. Their structures were determined through extensive spectroscopic data (IR, MS, 1H NMR, 13C NMR, HSQC, HMBC, COSY, and NOESY) and by comparison of the spectral data with those of the related known compounds. The structure of compound 1 is rare due to the presence of a tetrahydropyran ring constituted from C2-C6 and oxygen atom. Compound 7 is the first discovery of eunicellin-based dimer.
    The anti-inflammation activity of twelve compounds (1–6 and 8–13) at 10 μM was studied. The results showed that compound 4 inhibited more than 70% express of elastase released in FMLP/CB-induced human neutrophils .
    Advisory Committee
  • Chang-Yih Duh - chair
  • Chih-Chuang Liaw - co-chair
  • Fang-Rong Chang - co-chair
  • Jyh-Horng Sheu - advisor
  • Files
  • etd-0828112-140112.pdf
  • Indicate in-campus at 5 year and off-campus access at 5 year.
    Date of Submission 2012-08-28

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