Title page for etd-0827107-112806


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URN etd-0827107-112806
Author Yueh-hua Chung
Author's Email Address No Public.
Statistics This thesis had been viewed 5569 times. Download 1143 times.
Department Biological Sciences
Year 2006
Semester 2
Degree Master
Type of Document
Language English
Title The role and effect of bone morphogenetic protein-2 in liver fibrosis
Date of Defense 2007-07-13
Page Count 63
Keyword
  • liver fibrosis
  • Bone morphogenetic protein-2
  • Abstract Bone Morphogenetic proteins (BMPs) belong to transforming growth factor beta (TGF-β) superfamily. They regulate cell proliferation, cell differentiation, and bone morphogenesis. Previous evidence suggests that BMP-2, as an antagonist of TGF-β, may play an inhibitory role in tissue fibrogenesis. The aim of this study is to examine the expression profile of BMP-2 in fibrotic livers and to test whether BMP-2 gene delivery could alleviate or reverse the liver fibrogenesis models in mice including bile duct ligation (BDL) or carbon tetrachloride (CCl4) model. The results showed that the AST, ALT, and bilirubin levels in sera and the expression of TGF-β, α-smooth muscle actin, type I collagen in livers were significantly up-regulated by BDL surgery or CCl4 administration. After BDL, the hepatic BMP-2 mRNA and protein levels in mice decreased at 7 and 14 days after surgery. Similarly, the hepatic BMP-2 mRNA and protein levels in mice decreased at day 14 and 28 after CCl4 administration. BMP-2 gene delivery alleviated the inflammation and the liver injury caused by BDL or CCl4 exposure. These findings strongly suggest that BMP-2 is involved in the pathogenesis of liver fibrosis. Moreover, BMP-2 supplementation may facilitate a novel strategy for treatment of liver fibrosis.
    Advisory Committee
  • Cho Chung-Lung - chair
  • Hu Tsung-hui - co-chair
  • Tai Ming-Hong - advisor
  • Files
  • etd-0827107-112806.pdf
  • indicate accessible in a year
    Date of Submission 2007-08-27

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