Title page for etd-0825113-002013


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URN etd-0825113-002013
Author Chien-yi Wu
Author's Email Address wucyi1228@yahoo.com.tw
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Department Biological Sciences
Year 2013
Semester 1
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Relationship of Urinary Neutrophil Gelatinase-associated Lipocalin and Uromodulin with Chronic Kidney Disease
Date of Defense 2013-08-28
Page Count 41
Keyword
  • Chronic Kidney Disease (CKD)
  • Gout
  • Estimated glomerulus filtration rate (eGFR)
  • Neutrophil Gelatinase-associated Lipocalin (NGAL)
  • Uromodulin (UMOD)
  • Abstract The link between neutrophil gelatinase-associated lipocalin ( NGAL) and uromodulin (UMOD) with chronic kidney disease (CKD) has attracted much interest in the medical literature. Several investigations showed UMOD had active role in CKD progression. A total of 77 Taiwanese patients with stable disease activity selected from the cohort that attended our renal and rheumatology outpatient department were enrolled. Their demographic data, laboratory tests including urinary microalbumiuria excretion, serum creatinine, serum uric acid, eGFR, and urinary creatinine, NGAL and UMOD level were measured. The results showed that urinary NGAL excretion correlated negatively with eGFR, and urinary UMOD excretion correlated positively with eGFR. Gender and urinary NGAL excretion did not differ between the CKD and non-CKD groups. However, age (CKD group: 64.5± 12.13 years, Non-CKD group: 47.03±11.87 years, p< 0.0001) and serum uric acid (CKD group: 8.12 ± 2.32 mg/dl, Non-CKD group: 6.39 ± 1.72 mg/dl, p<0.001) were significantly different between groups. Using multivariate analysis, patients with CKD had lower urinary UMOD excretion (Odds Ratio 0.82, 95% confidence interval: 0.69-0.98, p=0.029), and were more likely to be older (p< 0.01). Urinary NGAL excretion, urinary albumin excretion, status of diabetic mellitus, hypertension, gout were not associated with status of CKD. Our study indicated that UMOD might play a role in the development of CKD. Urinary NGAL excretion was not associated with gout or CKD. Further studies with animal model of gout and CKD are mandatory to establish fundamental pathological mechanism and explore the clinical implications
    Advisory Committee
  • Chung-Lung Cho - chair
  • Feng-Rong Chuang - co-chair
  • Hsueh-Wen Chang - advisor
  • Files
  • etd-0825113-002013.pdf
  • indicate access worldwide
    Date of Submission 2013-09-25

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