Title page for etd-0824105-181306


[Back to Results | New Search]

URN etd-0824105-181306
Author Wan-wen Su
Author's Email Address No Public.
Statistics This thesis had been viewed 5564 times. Download 5471 times.
Department Biological Sciences
Year 2004
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Plasma Level and 3’-Untranslated Region +62 G/A
Polymorphism of Resistin in Taiwanese with Metabolic Syndrome and Ischemic Cerebral Vascular Disease
Date of Defense 2005-07-11
Page Count 61
Keyword
  • Resistin
  • Ischemic Cerebral Vascular Disease
  • Metabolic Syndrome
  • Abstract Resistin is an adipocytokine derived from adipose tissue. Studies showed that resistin is not only related to insulin resistance, but also possibly an important factor related to activating of inflammation and atherosclerosis. It influences the endothelial cells and the function of vessel. To investigate whether or not resistin play a role in the metabolic syndrome and ischemic stroke. we examined the plasma resistin concentrations as well as the 3’ untranslated region +62 G/A polymorphism of resistin gene in a Taiwan population.
    In the first part of this study, 112 patients with ischemic cerebral vascular disease and 110 healthy subjects were included and analyses of demographic and biochemical parameter, high sensitive C-reactive protein and plasma resistin concentration measurements were performed. In the second part, 594 patients with ischemic cerebral vascular disease and 799 healthy control were examined for resistin 3’ untranslated region +62 G/A polymorphism. Resistin concentration was analyzed by EIA method, and resistin 3’ untranslated region +62 G/A polymorphism was done by PCR and RFLP.
      The mean plasma resistin concentration of 112 patients with ischemic cerebral vascular disease was significantly lower than that of the 110 controls (32 ± 59.7 ng/ml and 55.7 ± 82.5 ng/ml, p < 0.001).When the concentration of resistin was divided into 4 groups and analyzed as continuous variable, it was found that decreased plasma resistin concentration is associated with increased risk of ischemic cerebral vascular disease. After the multiple adjustment by logistic analysis, the adds ratio for the first, second and third quadrate were 7.8, 5.0 and 0.1, respectively).
       The genotype analysis of 594 patients with ischemic cerebral vascular disease and 799 healthy controls show that the resistin genotype was related statistically to the risk of ischemic stroke. In multiple regression analysis, resistin 3’ untranslated region +62 G/A polymorphism was significantly associated with diastolic blood pressure (GA + AA : GG = 142.2 ± 19.2 : 139.3 ± 20.7 mmHg, p = 0.044) and fasting plasma sugar (GA + AA : GG : 83.4 ± 13.1 : 81.1 ± 13.1 mg/dl , p = 0.005).
      Our results indicated that resistin may be related to metabolic syndrome and ischemic cerebral vascular disease and possibly play a role in the development of atherosclerosis.
    Advisory Committee
  • Ching-Mei Hsu - chair
  • Shiping He - co-chair
  • Chung-Lung Cho - advisor
  • Yau-Jiunn Lee - advisor
  • Files
  • etd-0824105-181306.pdf
  • indicate accessible in a year
    Date of Submission 2005-08-24

    [Back to Results | New Search]


    Browse | Search All Available ETDs

    If you have more questions or technical problems, please contact eThesys