Title page for etd-0816113-115809


[Back to Results | New Search]

URN etd-0816113-115809
Author Wei-Hao Wu
Author's Email Address eva210119@gmail.com
Statistics This thesis had been viewed 5571 times. Download 0 times.
Department Marine Biotechnology and Resources
Year 2013
Semester 1
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title The anti-neuroinflammatory effects of a synthetic marine-derived compound on STZ induced diabetic rats
Date of Defense 2013-08-23
Page Count 137
Keyword
  • neuroinflammation
  • immunohistochemistry
  • transforming growth factor-β
  • antinociceptive effects
  • Abstract Diabetes mellitus is a metabolic disease that can have long-term complications, including diabetic neuropathy pain. Base on preliminary screening, we had found that a marine-derived compound, SWV-1 has potential in vitro anti-inflammatory effects. In present study, we found that intrathecal or oral SWV-1 produce antinociceptive effects in STZ-induced diabetic neuropathic rats. Moreover, compare with ziconotide, SWV-1 did not produced any obvious adverse effects. Immunohistochemistical analyses also showed that SWV-1 significantly attenuated STZ-induced spinal neuroninflammation. We further demonstrated that administration of TGF-β type I receptor inhibitor attenuate the analgesic effect of SWV-1 in STZ-rats. In conclusion, SWV-1 is a potential candidate compound for drug development to treat neuropathic pain in patients with diabetes.
    Advisory Committee
  • Jyh-Yih Chen - chair
  • San-Nan Yang - co-chair
  • Zhi-Hong Wen - advisor
  • Files
  • etd-0816113-115809.pdf
  • Indicate in-campus at 99 year and off-campus access at 99 year.
    Date of Submission 2013-09-27

    [Back to Results | New Search]


    Browse | Search All Available ETDs

    If you have more questions or technical problems, please contact eThesys