Title page for etd-0810114-102730


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URN etd-0810114-102730
Author Wen-ya Yang
Author's Email Address No Public.
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Department Marine Biotechnology and Resources
Year 2013
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title The neuroprotectective effects of soft coral-derived compounds
Date of Defense 2014-07-25
Page Count 133
Keyword
  • 6-OHDA
  • SH-SY5Y
  • ROS
  • Parkinson’s disease
  • HO-1
  • Abstract Parkinson’s disease (PD), after Alzheimer’s disease, is one of most common age-related neurodegenerative diseases, affects almost 0.2% of the world population. Till date, few pharmacological agents have been isolated that effectively inhibit the progression of PD; although these agents have been proven to be effective in providing symptomatic relief against PD, they have also been reported to cause undesirable side effects that result in long-term oxidative damage. In the present study, PWY21 and PWY29 were isolated from marine organisms. They significantly reduced 6-OHDA-induced cytotoxicity and apoptosis in human neuroblastoma (SH-SY5Y). The cellular neuroprotective effect of PWY21 and PWY29 were tested in 6-OHDA-treated SH-SY5Y cells, wherein neuroprotection is mediated through modulation of oxidative stress. Moreover, we also found PWY21 and PWY29 also attenuated 6-OHDA-induced motor behavior dysfunction in zebrafish. Therefore, we conclude that PWY21 and PWY29 may be promising candidates for the treatment of PD
    Advisory Committee
  • Wu-Fu Chen - chair
  • San-Nan Yang - co-chair
  • Zhi-Hong Wen - advisor
  • Files
  • etd-0810114-102730.pdf
  • Indicate in-campus at 99 year and off-campus access at 99 year.
    Date of Submission 2014-09-10

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