Title page for etd-0807112-221354


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URN etd-0807112-221354
Author Yi-syuan Lu
Author's Email Address No Public.
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Department Materials and Optoelectronic Science
Year 2011
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Using Hydrogen-Bonding Interactions to Control the Peptide Miscibility and Secondary Structures
Date of Defense 2012-06-25
Page Count 49
Keyword
  • Complexes
  • Polypeptides
  • Hydrogen-Bond interactions
  • Polymer blends
  • Abstract In this study we synthesized poly(tyrosine) (PTyr) through living ring-opening polymerization of α-amino acid-N-carboxyanhydride and then blended with poly(4-vinyl pyridine) (P4VP) homopolymer in N, N-dimethylformamide (DMF) and methanol solutions to control the miscibility behavior and the secondary structures of poly(tyrosine). Infrared spectrum analysis suggests that the mixture of PTyr/P4VP possesses strong hydrogen-bonding interaction between the hydroxyl group of PTyr and the pyridine group of P4VP. DSC analyses indicate that these PTyr/P4VP complexes from methanol solution always have higher glass transition temperatures than the corresponding PTyr/P4VP miscible blends obtained from DMF solution. We proposed that the polymer chain behavior of PTyr/P4VP blend from DMF solution is the separated random coil and thus the PTyr chain possesses the random coil secondary structure after solvent evaporation. However, by increasing the hydrogen bonding for PTyr/P4VP complex from methanol solution, inter-polymer complex aggregate is proposed and the corresponding chain behavior enhances the intermolecular hydrogen bonding interaction of PTyr with P4VP that results in the β-sheet conformation based on Fourier transforms infrared (FTIR), solid state nuclear magnetic resonance (NMR) spectroscopy, and wide-angle X-ray diffraction analyses.
    Advisory Committee
  • Ching-Hsuan Lin - chair
  • Chih-Feng Wang - co-chair
  • Ming Chen - co-chair
  • Chih-Feng Huang - co-chair
  • Shiao-Wei Kuo - advisor
  • Files
  • etd-0807112-221354.pdf
  • Indicate in-campus at 2 year and off-campus access at 2 year.
    Date of Submission 2012-08-07

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