Title page for etd-0806117-171028


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URN etd-0806117-171028
Author Sheng -yuan Chen
Author's Email Address No Public.
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Department Business Management
Year 2017
Semester 1
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Long-term outcomes after the percutaneous treatment of drug-eluting stent restenosis
Date of Defense 2017-09-06
Page Count 42
Keyword
  • DES-ISR
  • MACCE
  • DEB
  • DES
  • Abstract In-stent restenosis (ISR) is still a common problem even in the drug-eluting stent (DES) era. The optimal treatment strategy is still controversial. This study aimed to evaluate the long-term clinical outcomes after the treatment of DES in-stent restenosis (DES-ISR) on the basis of the initial strategy of using a drug-eluting balloon (DEB) or repeated DES implantation. From Jan 2011 to Dec 2015 , 4898 consecutive patients underwent percutaneous coronary intervention with DES in our hospital. Of the patients,540 with DES-ISR treated with either DEB (n = 338) or DES (n = 202) constituted the study population. Major adverse cardiovascular and cerebrovascular events (MACCE), including death, non-fatal myocardial infarction, non-fatal stroke, and target lesion revascularization (TLR) were analyzed. Differences in baseline and angiographic characteristics were not significant between the groups. The total incidence of MACCE was 13.51% (DEB vs DES group: 12.13% vs. 15.84%; P = 0.283). The 5-year incidence rates of MACCE were similar between the groups. Multivariable Cox regression analysis revealed that shorter time interval to DES-ISR,CABG, and initial first-generation DES-ISR were independent risk factors of MACCE. Long-term outcomes were comparable between the DEB and DES groups. Shorter time interval to first DES-ISR, CABG, initial first generation DES-ISR were important predictors of future MACCE and TLR after reintervention for DES-ISR.
    Advisory Committee
  • Wei-chuen Huang - chair
  • Ying-kai Chen - co-chair
  • Ying-chun Li - advisor
  • Files
  • etd-0806117-171028.pdf
  • Indicate in-campus at 0 year and off-campus access at 1 year.
    Date of Submission 2017-09-06

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