Title page for etd-0804109-165826


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URN etd-0804109-165826
Author Mei-ru Lin
Author's Email Address linmeiru@hotmail.com
Statistics This thesis had been viewed 5566 times. Download 815 times.
Department Marine Biotechnology and Resources
Year 2008
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Studies on the Briarane-type Diterpenoids from a Cultured Octocoral Briareum excavatum
Date of Defense 2009-07-24
Page Count 387
Keyword
  • Briareum excavatum
  • Abstract In the continuing search for novel substances from marine invertebrates originally distributed in Taiwan waters. The octocoral Briareum excavatum was transplanted to the culturing tanks located in the NMMBA for its interesting chemical constituents. This study had led to the isolation of 32 briarane derivatives 1–32, including 18 new compounds,
    briaexcavatins I–Z (1–18) from the cultured B. excavatum. The structures of compounds
    1–32 were determined by spectroscopic methods and the structures of briaexcavatins I (1), U (13), W (15) and the known compound excavatolides C (19) and E (20) were confirmed by X-ray data analysis. The absolute configurations of briaranes 13 and 20 were determined by X-ray diffraction analysis and modified Mosher’s method, respectively. It is noteworthy
    to mention that briaexcavatin Y (17) represents the first example of a briarane possessing a C-8/9 epoxy group. The relationships between 13C NMR chemical shifts and the conformations of the briaranes possessing an 11,12-epoxy group are described.
    In biological activity experiments, briaranes 11, 19, and 24 exhibited weak cytotoxicity toward CCRF-CEM tumor cells and compounds 2 and 19 showed weak
    cytotoxicity toward DLD-1 tumor cells, respectively. Moreover some of these briaranes such as compounds 24, 26, and 27 have displayed mild inhibitory effects on superoxide anion generation by human neutrophils. Compounds 14, 24, 26, and 30 showed mild inhibitory effects on human neutrophil elastase release. Compound 18 exhibited mild
    activity to enhance human neutrophil elastase release.
    Advisory Committee
  • Yang-Chang Wu - chair
  • Fang-Rong Chang - co-chair
  • Ping-Jyun Sung - advisor
  • Jyh-Horng Sheu - advisor
  • Files
  • etd-0804109-165826.pdf
  • indicate access worldwide
    Date of Submission 2009-08-04

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