Title page for etd-0730108-135015


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URN etd-0730108-135015
Author Bi-yao Lee
Author's Email Address No Public.
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Department Institute of Biomedical Sciences
Year 2007
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Investigations of The Effects of Glucocorticoid Receptor SNPs and SUMO-2 Autoantibody in Patients with Systemic Lupus Erythematosus
Date of Defense 2008-07-22
Page Count 103
Keyword
  • polymorphism
  • SUMO-2
  • glucocorticoid receptor
  • SLE
  • Abstract For more than fifty years glucocorticoids (GCs) has been used to treat a
    wide range of inflammatory diseases, such as allergies, asthma, rheumatoid
    arthritis, and autoimmune diseases, due to its potentiality on the antiinflammatory
    and immunomodulatory effects. The anti-inflammation actions
    of glucocorticoid were mediated by an intracellular receptor, glucocorticoid
    receptor (GR), a member of the nuclear receptor family of ligand-dependent
    transcription factor. Upon activation by their ligand, GRs translocated to the
    nuclear and then bound to glucocorticoid responsive element (GRE) or
    negative glucocorticoid responsive elemen (nGRE). The administration of
    GCs depended on the acuity of disease and on the responses of patient
    clinically. Although some Systemic Lupus Erythematosus (SLE) patients
    given the maximal steroid doses, the response to the therapy remained
    poorly, and thus called “glucocorticoid resistance”. Despite the fact that the
    side effects and complications in SLE patients may result from the
    restrictions of physic; it has been documented that there were some
    relationships between the glucocorticoid resistance with the polymorphisms
    of GR, and the levels of glucocorticoid receptor beta. However, no
    significant differences in the GR polymorphisns (TthIII, ER22/23EK, N363S,
    BclI and I559N) between controls and SLE patients were found and there
    were no significant differences found on the levels of SUMO-2 antibody
    between patients with active and inactive SLE in this study. Neverthless, a
    significant association on the the allelic polymorphism of BclI was observed
    in patients with glucocorticoid resistance. Additionally, the expression of
    GRβ in patients with SLE was higher than that of controls and the TthIII CT
    genotype was associated with GRα expression.
    Advisory Committee
  • Hurng-Wern Huang - chair
  • Deng-Chyang Wu - co-chair
  • Angela Chen - advisor
  • Files
  • etd-0730108-135015.pdf
  • indicate in-campus access in a year and off_campus not accessible
    Date of Submission 2008-07-30

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