Title page for etd-0730108-134947


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URN etd-0730108-134947
Author Yu-chen Tsao
Author's Email Address No Public.
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Department Institute of Biomedical Sciences
Year 2007
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title A Prospective Small Volume Albumin Therapy in Cirrhosis and
Spontaneous Bacterial Peritonitis Treatment
Date of Defense 2008-07-22
Page Count 96
Keyword
  • cirrhosis
  • spontaneous bacterial peritonitis
  • albumin
  • Abstract In clinical findings, complications are the major cause of death in
    cirrhotic patients. Among all the complications, ascites is most frequent
    type. All cirrhotic patients with ascites could develop spontaneous
    bacterial peritonitis (SBP). The hospitalized prevalence of SBP was high
    (30%) in cirrhotic ascites patients. However, the outcome of cirrhotic
    SBP patients has been improved because of using the antibiotics
    cephalosporins. Furthermore, treatment with intravenous albumin in
    addition to cephalosporins reduced the incidence of renal impairment and
    the mortality in SBP patients in a multicentre study. However, other
    studies showed that administration of albumin might not work as
    effectively as other plasma expanders do. Moreover, administration of
    large volume albumin would make the medication very expensive and
    might have potential risk of infectious disease, since the therapeutic
    albumin is extracted from human plasma. Therefore, to treat patients with
    large volume albumin become disputable. In this study, we evaluated the
    effects of small volume intravenous albumin with cephalosporins
    treatments through monitoring patients’ renal and hepatic functions and
    related inflammatory markers. Results showed that plasma TNF-α, ΙL-6
    and ascites endotoxin, TNF-α and IL-6 levels were significantly reduced
    in patients treated with cephalosporins plus small volume albumin, but
    not in those treated with cephalosporins alone. Also, the combination
    therapy of cephalosporins and small volume albumin avoid the
    dramatically elevation of plasma and ascites nitric oxide, as well as the
    further degree of renal function impairment. The positive results of this
    study laid a solid foundation for a large scale investigation.
    Advisory Committee
  • Wen-chun Hung - chair
  • Deng-chyang Wu - co-chair
  • Angela Chen - advisor
  • Files
  • etd-0730108-134947.pdf
  • indicate in-campus access in a year and off_campus not accessible
    Date of Submission 2008-07-30

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