Title page for etd-0728118-203208


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URN etd-0728118-203208
Author Hong-Jyun Wang
Author's Email Address No Public.
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Department Institute of Medical Science and Technology
Year 2018
Semester 1
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Rapid in situ gelation by blue light-irradiation for combination therapy in brain tumor.
Date of Defense 2018-08-08
Page Count 95
Keyword
  • Hydrogel
  • Brain tumor
  • Drug delivery
  • Combination therapy
  • Photothermal therapy
  • Gelatin methylacrylate
  • Abstract About 40,000 people are diagnosed with primary brain tumors in the United States each year, an estimated 15,000 have glioblastoma multiforme (GBM), still associated with poor prognosis with 14.6 months of median survival after surgical resection combined with chemotherapy and radiation. Preventing tumor from post-surgical recurrence is a significant clinical challenge since current methods deliver chemotherapeutic agents in a rapid manner and are not effective against the residual tumor cells, such as GliadelĀ® . To overcome this drawback, we develop a blue light-crosslinking hydrogel which can be rapidly gelled in situ and tightly adhere on the tissues for controlled chemotherapy, radiotherapy, and enhanced laser interstitial thermal therapy (LITT) to inhibit residual tumor cells from  post-surgical recurrence. The principle goals are to i) determine the prevailing factors that affect efficient encapsulation of chemotherapeutic drugs (i.e., Epirubicin) and radio-sensitizer (i.e., Cisplatin) within hydrogels, ii) demonstrate efficiency of gelation, LITT enhancement, in vitro drug release, iii) evaluate the efficiency in human cancer cells and in vivo tumor model. Thus, we used gelatin, a highly biocompatible material which derived from collagen, as hydrogel scaffold to encapsulate small molecule drug (Epirubicin and Cisplatin). Our results have demonstrated that this multi-treatment system can effectively prevent tumor recurrence and significantly prolong the medium survival of gliosarcoma-bearing (MBR-614 or U87-MGFL) mice to above 65 days compared with the control group (36 days). We believe this synergistic strategy presents a new approach to the development of a local drug delivery system for the prevention of brain tumor recurrence.
    Advisory Committee
  • Wei, Kuo-Chen - chair
  • Wang, Hay-Yan - co-chair
  • Hung-Wei Yang - advisor
  • Files
  • etd-0728118-203208.pdf
  • Indicate in-campus at 3 year and off-campus access at 5 year.
    Date of Submission 2018-08-30

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