Title page for etd-0727118-160558


[Back to Results | New Search]

URN etd-0727118-160558
Author Tian-Sheng Yang
Author's Email Address No Public.
Statistics This thesis had been viewed 5573 times. Download 0 times.
Department Marine Biotechnology and Resources
Year 2017
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Continuous Investigation on the Secondary Metabolities and Biological Activities from a Formosan Soft Coral Lobophytum varium
Date of Defense 2018-07-18
Page Count 187
Keyword
  • cytotoxic activitiy
  • diterpenoids
  • secondary metabolites
  • Lobophytum varium
  • soft coral
  • Abstract In order to discover bioactive secondary metabolites, we continued the chemical investigation of the ethyl acetate extract of a Formosan soft coral Lobophytum varium, collected from the Jihui Fishing Port, Taitung, Taiwan in 2013. This study further led to the isolation of ten natural products, including one new lobane-type diterpenoid lobovarol L (1) and five new prenyleudesmane-type diterpenoids lobovarols M─Q (2─6), along with four known compounds: lobatrienolide (7), loba-8,10,13(15)-triene-
    14,17,18-triol 14-acetate (8), loba-8,10,13(15)-triene-14,17,18-triol 14,17-diacetate (9), lobovarol I (10). The chemical structures of compounds 1─10 were elucidated on the basis of spectroscopic methods (IR, MS, 1D and 2D NMR), and by comparison of the spectroscopic data with the related known diterpenoids.
    The cytotoxicity of compounds 1─10 against P388 (mouse lymphocytic leukemia), DLD-1 (human colon adenocarcinoma), CCD-966SK (human skin fibroblast) cell lines were evaluated. The results showed that compounds 2 exhibited cytotoxicity against CCD-966SK cell line with an IC50 value of 15.5 μg/mL. In anti-inflammatory assay, none of compounds show significant anti-inflammatory activity by inhibiting superoxide anion generation and elastase release in fMLF/CB-stimulated human neutrophils at 1 μM .
    Advisory Committee
  • Yang-Chang Wu - chair
  • Chih-Chuang Liaw - co-chair
  • Jyh-Horng Sheu - co-chair
  • Yuan-Bin Cheng - co-chair
  • Jyh-Horng Sheu - advisor
  • Files
  • etd-0727118-160558.pdf
  • Indicate in-campus at 5 year and off-campus access at 5 year.
    Date of Submission 2018-08-27

    [Back to Results | New Search]


    Browse | Search All Available ETDs

    If you have more questions or technical problems, please contact eThesys