Title page for etd-0726116-133400


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URN etd-0726116-133400
Author Hsing Yu Chang
Author's Email Address No Public.
Statistics This thesis had been viewed 5569 times. Download 326 times.
Department Marine Biotechnology and Resources
Year 2015
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Studies on the Secondary Metabolites from the Soft Coral Heteroxenia mindorensis
Date of Defense 2016-06-30
Page Count 225
Keyword
  • cytotoxicity
  • sesquiterpenoids
  • muurolane
  • Heteroxenia mindorensis
  • Abstract The distinct biodiversity of marine habitats is reflected by the structural and bioactivity diversity of secondary metabolites found in marine organisms. In order to search for novel and bioactive secondary metabolites, chromatographic separation on the acetone extract of the soft coral Heteroxenia mindorensis, collected at the Green Island resulted in the isolation of eight new muurolane sesquiterpenoids 1–8, one new germacrane sesquiterpenoid 10, one new oplopane sesquiterpenoid 11 and one known analogue γ-muurolene (9). The structures of these sesquiterpenoids were elucidated on the basis of their spectroscopic analyses comprising IR, UV, LRESIMS, HRESIMS, LREIMS, 1D NMR, 2D NMR, and by comparison with reported data in literatures. The absolute stereochemistry of 1 was further determined by application of the Mosher’s method. The cytotoxicity of metabolites 1–11 against HT-29 (human colon adenocarcinoma) and A-549 (human lung epithelial carcinoma) cells were evaluated in vitro. Metabolites 1 and 8 exhibited significant cytotoxic activity against A-549. Metabolites 2 and 9 exhibited significant cytotoxic activity against HT-29.
    Advisory Committee
  • Jyh-Horng Sheu - chair
  • Yuan-Bin Cheng - co-chair
  • Shi-Yie Cheng - co-chair
  • Cheng-Yeh Duh - advisor
  • Files
  • etd-0726116-133400.pdf
  • Indicate in-campus at 0 year and off-campus access at 1 year.
    Date of Submission 2016-08-26

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