| Abstract |
Inhibin and activin are disulphide-linked dimeric proteins that belong to the transforming growth factor superfamily. Inhibin and activin are identified that they have ability to modulate the secretion of follicle-stimulating hormone, FSH, from pituitary. Activin can stimulate FSH secretion, on the other hand, inhibin can inhibit
FSH production. According to many researches, inhibin and activin play an important
roles in regulation of reproduction. Black porgy (Acanthopagrus schlegeli) is belong
to protandry.that has a complex regulation in sex differentiation and development. The
male differentiation in black porgy started at fourth month, and the testis become
mature when the spawing season coming.in the first two year in black porgy, they are
differentiate to functional males, and some of them will change to females in the third
year. The objectives were to study the possible roles of inhibin、activin subunits and
their receptors in sex differentiation and sex change in black porgy. The gene
expression of activin system increase during the period of ovarian development. The
expression of activin receptors in ovarian tissue are higher than in testis tissue in the
testis-excision experiment. The expression of inhbab 、acvr1and acvr2b after
testis-excision are higher than in control in black porgy forebrain. The expression of
inhbaa increase at four to five months after hatching in 0+-yr old black porgy, and the
expression of inhbb and receptors decrease at the same time. According to these
results, activin system may involve in the ovarian development and mature, and play
important roles in testis differentiation and development in black porgy. Furthermore,
activin system have sex dimorphisms in forebrain in black porgy. |
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