Title page for etd-0721117-110326


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URN etd-0721117-110326
Author Yi-Ting Hsu
Author's Email Address lavender4999@gmail.com
Statistics This thesis had been viewed 5579 times. Download 41 times.
Department Biological Sciences
Year 2016
Semester 2
Degree Master
Type of Document
Language English
Title A Study on the Levels of Heavy Metals in Patients with Acute Ischemic Stroke
Date of Defense 2017-07-18
Page Count 42
Keyword
  • acute ischemic stroke
  • heavy metal
  • stroke
  • lead
  • arsenic
  • cadmium
  • mercury
  • Abstract Few studies examining the relationship between heavy metal amounts and stroke incidence have been reported. The aim of this study was to explore the relationship between heavy metal levels, including lead (Pb), mercury (Hg), arsenic (As) and cadmium (Cd), in patients with acute ischemic stroke (AIS). We selected patients with first-ever AIS onset within one week as our study group. Healthy controls were subjects without history of stroke or chronic disease, except hypertension. Patients and controls were initially studied to determine the serum level of Pb, Hg, As and Cd. All subjects received 1 gm infusion of edetate calcium disodium (EDTA). The urine specimen were collected for 24 hours after EDTA infusion and measured for the heavy metal levels. Thirty-three patients with AIS and 39 healthy controls were enrolled in this study. The major findings are: (1) The stroke group had a higher urine level of Cd compared to healthy control (2.05 ± 2.17 vs. 1.22 ± 0.99 μg/L, P= 0.048); (2) The stroke group had a lower serum level of Hg (6.35 ± 4.26 vs. 9.76 ± 7.03 μg/L, P= 0.015) and lower urine level of Hg (1.31 ± 1.14 vs. 2.00 ± 1.16 μg/L, P= 0.013) compared to healthy control. These findings indicate a higher level of urine Cd and lower levels of Hg in serum and urine of first-ever AIS patients, providing new evidence for potential association of dysregulated heavy metals in patients with AIS. Further studies are required to elucidate the roles of the identified heavy metals in the prevalence of AIS.
    Advisory Committee
  • Chang, Hsueh-Wen - chair
  • Lee, Kun-Ze - co-chair
  • Chan, Julie YH - advisor
  • Files
  • etd-0721117-110326.pdf
  • Indicate in-campus at 2 year and off-campus access at 2 year.
    Date of Submission 2017-08-21

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