Title page for etd-0715117-084334


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URN etd-0715117-084334
Author Pei-hua Yang
Author's Email Address No Public.
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Department Biological Sciences
Year 2016
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Study the mechanisms of Pentabromophenol in the modulation of TGF-β signaling.
Date of Defense 2017-06-28
Page Count 77
Keyword
  • BFR
  • EMT
  • Smad
  • TGF-β
  • PBP
  • Abstract Pentabromophenol (PBP), a brominated flame retardant (BFR), is widely used in various consumer products. BFRs exert adverse health effects such as neurotoxic and endocrine-disrupting effects. In this study, we found that PBP suppressed TGF-β responsiveness by accelerating the turnover rate of TGF-β receptor. PBP suppressed TGF-β1-mediated cell migration, PAI-1 reporter gene activation and Smad2/3 activation in various type of cells, abolished TGF-β1-mediated repression of E-cadherin expression, as well as induction of vimentin expression along with Snail and Slug upregulation; thus, blocking the TGF-β1-mediated epithelial-to-mesenchymal transition (EMT) in A549 calls. TGF-β superfamily is a key player in the regulation of a wide variety of biological processes from development to pathogenesis including cell proliferation, migration, and the process of cancer development and progression. The in vitro results in this study provide a basis for studies of more detailed relationships between PBP and the modulation of TGF-β signaling. Because PBP is similar to other BFRs such as polybrominated diphenyl ethers (PBDEs), additional laboratory and mechanistic studies should be performed to examine BFRs as potential risk factors for tumorigenesis and other TGF-β-related diseases.
    Advisory Committee
  • Chiu, Chien-Chih - chair
  • Wu, Chang-Yi - co-chair
  • Wen, Zhi-Hong - co-chair
  • Chen, Chun-Lin - advisor
  • Files
  • etd-0715117-084334.pdf
  • Indicate in-campus at 5 year and off-campus access at 5 year.
    Date of Submission 2017-08-15

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