Title page for etd-0712115-154806


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URN etd-0712115-154806
Author Wan-Ting Teng
Author's Email Address No Public.
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Department Marine Biotechnology and Resources
Year 2014
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Lobane Diterpenes and their Biological Activities from Formosan Soft Coral Lobophytum varium
Date of Defense 2015-07-10
Page Count 160
Keyword
  • natural product
  • soft coral
  • Lobophytum
  • lobane
  • bioactivity
  • Abstract In order to discover bioactive secondary metabolites, we have studied the chemical consitutents from the organic extracts of the soft coral Lobophytum varium, which collected from Jihui Fish Port, Taitung, Taiwan. This study had led to isolation of twelve natural compounds 1―12, containing five new lobane diterpene derivatives, lobovarols A―E (1―5) along with seven known compounds 6―12. The structures and relative configurations of all metabolites had been established by detailed spectroscopic analysis including 1D and 2D NMR (1H, 13C, 1H–1H COSY, HSQC, HMBC and NOESY) data in association with MS experiments. None of the result of cytotoxicity assay against the A549, LN-cap and DLD-1 shows all compounds had significant cytotoxicity. Anti-inflammation assay, compounds 3―5 and 11 were found to show inhibiting activities.
    Advisory Committee
  • Yang-Chang Wu - chair
  • Ping-Jyun Sung - co-chair
  • Fang-Rong Chang - co-chair
  • Jyh-Horng Sheu - advisor
  • Files
  • etd-0712115-154806.pdf
  • Indicate in-campus at 5 year and off-campus access at 5 year.
    Date of Submission 2015-08-12

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