Title page for etd-0712113-043830


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URN etd-0712113-043830
Author Tzu-zin Huang
Author's Email Address m005020001@nsysu.edu.tw
Statistics This thesis had been viewed 5581 times. Download 127 times.
Department Marine Biotechnology and Resources
Year 2012
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Secondary Metabolites and Biological Activities from the Soft Coral Cladiella hirsuta
Date of Defense 2013-07-16
Page Count 304
Keyword
  • soft coral
  • elastase
  • cytotoxicity
  • anti-inflammation
  • natural products
  • Abstract In order to discover for bioactive compounds, we studied the chemical constituents from the organic extracts of soft coral Cladiella hirsuta. This study had led to the isolation of 26 natural products, including ten eunicellin-type diterpenoids (1–10), two steroid glycosides (11–12), and two phenol glycosides (13–14), along with twelve known compounds (15–26). The structures of compounds 1–26 were established by spectroscopic methods and by comparison of the spectral data with those of the related known compounds.
    The cytotoxicity of compounds 1–10, 15–23 and 26 against the P388 (murine leukemia), K562 (human erythro myeloblastoid leukemia), HT-29 (human lung adenocarcinoma epithelial cell line) and A549 (human colon adenocarcinoma grade II cell line), compound 22 showed significant cytotoxicity against the all cancer cell lines with IC50 values of 5.4、4.0、1.6 and 13.2 μM, respectively.
    On the part of anti-inflammation assay, compounds 11 and 12 were found to show effectively inhibiting activity of elastase release with IC50 values of 5.55 ± 1.34 and 4.12 ± 0.12, respectively.
    Advisory Committee
  • Fang-Rong Chang - chair
  • Chih-Chuang Liaw - co-chair
  • Jyh-horng Sheu - advisor
  • Files
  • etd-0712113-043830.pdf
  • Indicate in-campus at 5 year and off-campus access at 5 year.
    Date of Submission 2013-08-12

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