Title page for etd-0702118-143707


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URN etd-0702118-143707
Author Bao-Jueng Wu
Author's Email Address No Public.
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Department Marine Biotechnology and Resources
Year 2017
Semester 2
Degree Ph.D.
Type of Document
Language zh-TW.Big5 Chinese
Title The molecular mechanisms of vascular malformation caused by zinc deficiency
Date of Defense 2018-05-31
Page Count 86
Keyword
  • caudal vein plexus
  • zinc deficiency
  • oxidative stress
  • zebrafish
  • vascular development
  • antioxidant gene
  • intersegmental vessels
  • Abstract Zinc is an essential nutrient for all organisms because it is required as a structural and catalytic cofactor by hundreds of proteins. Zinc deficiency is associated with increased levels of lipid and protein oxidation. In addition, the oxidative stress associated with zinc deficiency leads to increased levels of DNA damage. One previous study showed zinc deficiency can cause oxidative stress in yeast. Similar studies in animal and mammalian cells also showed that zinc limitation leads to increased oxidative stress. Many studies have been shown the connection between oxidative stress and vascular diseases. However, most studies have done in adult animals under pathological conditions, and very limited information about oxidative stress and vascular development during embryogenesis. Zinc is important in several biological processes including growth and development. Recent study showed zinc transporter LIV1 (Zip6) is important for Epithelial-mesenchymal transition (EMT) during the development mediated by STAT3/Snail signalings. However, it has limited knowledge regarding to the molecular mechanism on the impact of zinc deficiency in the developing embryo due to a lack of suitable experimental models, and no report has been shown the effect of zinc deficiency in vascular development yet.
      Our preliminary data showed that zinc deficiency results in the defect in vascular development at intersegmental vessels (ISVs) and caudal vein plexus (CVP). In addition, vascular specific markers showed reduced or ectopic expression, suggested the impacts of zinc deficiency in vascular development. Understanding the effects of zinc deficiency in the developmental process will help us to prevent the prenatal zinc-related symptoms that might cause severe developmental malformation, such as acrodermatitis enteropathica (AE), infantile hemangioma. In addition, zinc depletion might serve as a new therapy for anti-angiogenesis related disease, such as cancer.
    Advisory Committee
  • Chien-Chih Chiu - chair
  • Zhang Liyu - co-chair
  • Chieh-Yu Pan - co-chair
  • Jing-Ru Weng - co-chair
  • Yao-Chang Chen - co-chair
  • Wu, Chang-Yi - advisor
  • Wen Zhi-Hong - advisor
  • Files
  • etd-0702118-143707.pdf
  • Indicate in-campus at 99 year and off-campus access at 99 year.
    Date of Submission 2018-08-02

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