Title page for etd-0631113-170137


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URN etd-0631113-170137
Author Yung-yu Chu
Author's Email Address No Public.
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Department Materials and Optoelectronic Science
Year 2012
Semester 2
Degree Master
Type of Document
Language English
Title Antimicrobial Effects of Thin Film Metallic Glasses Deposited on Glass and 316L Stainless Steel
Date of Defense 2013-07-28
Page Count 132
Keyword
  • silver
  • cytotoxic
  • contact angle
  • antimicrobial effect
  • thin film metallic glass
  • Abstract Many studies show that silver is an effective antimicrobial agent. Thin film metallic glasses (TFMGs) exhibit excellent corrosion resistance and much better hydrophobic property. It follows that TFMGs might be promising for improving the surface properties and antimicrobial ability of substrates in biomedical applications. However, the development and investigation of antimicrobial ability and biocompatibility for metallic glasses are still rare. Besides, the mechanism of antimicrobial effects of TFMGs is still unknown. To understand the interaction between bacteria and TFMGs, it is investigated by comparing the antimicrobial activity between the Al48Ag37Ti15 TFMG, Zr54Ti35Si11 TFMG, and Zr59Ti22Ag19 TFMG. In this study, all the TFMGs were deposited on glass by co-sputtering processes. Afterward, the superior TFMGs were also deposited onto the modified 316L stainless steel (SS). The antimicrobial performances of the TFMGs are tested with Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa which are the most common nosocomial infection pathogens. The experimental results show that the antimicrobial effect of Al48Ag37Ti15 and Zr59Ti22Ag19 TFMG is almost similar to thin film of pure Ag. Moreover, the result of Zr54Ti35Si11 TFMG is shown to be non-cytotoxic to mouse bone marrow stem cells using an MTS assay for proliferation. These results are expected to impose significant contributions to the development of biomedical devices.
    Advisory Committee
  • Lin, Che-Hsin - chair
  • Liu, Jong-Kang - co-chair
  • J. C. Huang - advisor
  • Files
  • etd-0631113-170137.pdf
  • Indicate in-campus at 2 year and off-campus access at 2 year.
    Date of Submission 2013-07-31

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