Title page for etd-0627111-184422


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URN etd-0627111-184422
Author Ya-ting Chuang
Author's Email Address No Public.
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Department Mechanical and Electro-Mechanical Engineering
Year 2010
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Development of palladium nanoelectrode ensemble and its applications in chip-based electrochemical capillary electrophoresis
Date of Defense 2011-03-24
Page Count 75
Keyword
  • plasma etching
  • capillary electrophoresis
  • NEE
  • decoupler
  • electrochemical detection
  • Abstract This study demonstrates a high-performance capillary electrophoresis electrochemical (CE-EC) microchip featuring embedded the palladium nanoelectrode ensemble (Pd-NEE) as the decoupler. The Pd-NEE is fabricated utilizing a new composition of electroless plating bath for depositing palladium in the porous polycarbonate thin film. Palladium has the adsorbability and permeability to hydrogen, such that the produced Pd-NEE is able to eliminate the hydrogen formation from the high separation voltage and to reduce the background current for electrochemical detection. Moreover, this study adopts the oxygen plasma to etch the nanoelectrode ensemble to enlarge the exposed surface areas to further enhance the decoupling performance of the Pd-NRE. 
    Experimental results show that the developed Pd-NEE decoupler is capable of decoupling the electrophoretic current such that the hydrogen formation on the electrochemical electrodes was suppressed. Results indicate the developed Pd-NEE decoupler greatly enhance the S/N ratio for the electrochemical signal and lower the detectable concentration for the bio-sample of the dopamine and catechol. The detection limit of dopamine and catechol are 50 nM and 100 nM using the microchip with the Pd-NEE decoupler.
    Furthermore, results also indicate that the palladium nanorod ensemble (Pd-NRE) decoupler produced using the oxygen plasma etching of Pd-NEE have better electrochemical detection performance in compared with the Pd-NEE decoupler. The background current of the electrochemical detection obtained with the microchip with Pd-NRE decoupler is about 5.6 pA at applied electric field of 800 V/cm electric field. In addition, combining the gold nanorod ensemble (GNRE) as the working electrode, the detection limit is lower to 10 nM and 50 nM, respectively. This study presents a high efficiency CE-EC microchip with a Pd-NRE decoupler and a GNRE working electrode which not only decreases the background current but improves the detection limit.
    Advisory Committee
  • Shin-pon Ju - chair
  • Wei-lung Tseng - co-chair
  • Shiao-wei Kuo - co-chair
  • Che-hsin Lin - advisor
  • Files
  • etd-0627111-184422.pdf
  • indicate in-campus access in a year and off_campus not accessible
    Date of Submission 2011-06-27

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