Title page for etd-0617109-120417


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URN etd-0617109-120417
Author Ching-ping Yang
Author's Email Address ginglian2002@yahoo.com.tw
Statistics This thesis had been viewed 5567 times. Download 1902 times.
Department Institute of Health Care Management
Year 2008
Semester 2
Degree Master
Type of Document
Language English
Title The Prevalence and Clinical Correlative Factors of Peripheral Arterial Disease in Patients with Chronic Kidney Disease
Date of Defense 2009-06-10
Page Count 54
Keyword
  • Ankle brachial index
  • Chronic kidney disease
  • Calcium channel blocker
  • Pulse pressure
  • hypertension
  • Peripheral artery disease
  • Abstract Research Objective
    Patients with chronic kidney disease (CKD) are at increased risk for atherosclerosis and peripheral artery disease (PAD). PAD has received far less
    attention than coronary artery disease (CAD) in CKD patients. Few studies have examined risk factors for PAD in CKD. We studied the possible related risk factors and benefit of hypertension treatment in CKD patients with PAD.
    Data Sources
    We included 129 patients of both sexes with stages 3 to 5 of CKD, as described by the Kidney Outcome Quality Initiatives (K/DOQI ) classification, without
    receiving dialysis therapy, not previously diagnosed with PAD.
    Study Design
    The following information were collected within six month period, including demographic characteristics, history of hypertension, anti-hypertension drug, diabetes, smoking, and pre-existing cardiovascular disease, body mass index (BMI), fasting blood glucose, HbA1c, total cholesterol, triglyceride(TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol(LDL), calcium (Ca),
    phosphate(P), Albumin, uric acid, urine protein. Ankle-brachial index (ABI) is a noninvasive diagnostic test that is efficient in detecting asymptomatic PAD with ABI
    <0.9.
    Findings
    There were 22 (17.7 %) participants with PAD. Higher systolic blood pressure (SBP), higher diastolic blood pressure (DBP), higher pulse pressure showed strong association with PAD in CKD patients. On further analysis, significant fewer patients treated with calcium channel blocker (CCB) in hypertensive CKD patients with PAD (χ2 =7.055, p =0.008). The multivariate logistic regression analysis in hypertensive patients demonstrated the risk factors for PAD was pulse pressure, and Calcium channel blocker treatment may correlate with decreasing PAD formation (odds ratio= 0.232, 95% CI=0.07-0.73, p =0.013) in CKD patients.
    Conclusion
    There is a high prevalence rate of PAD in population of CKD, especially those with hypertension. ABI should be routinely examined in these patients who can benefit earlier from therapeutic measures.
    Advisory Committee
  • Meng-chiao Lin - chair
  • Ying-chun Li - co-chair
  • Shu-chuan Jennifer Yeh - advisor
  • Files
  • etd-0617109-120417.pdf
  • indicate in-campus access immediately and off_campus access in a year
    Date of Submission 2009-06-17

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