Title page for etd-0615109-173914


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URN etd-0615109-173914
Author Chia-Chi Yen
Author's Email Address No Public.
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Department Institute of Health Care Management
Year 2008
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title The efficacy after the treatment of combining hyaluronic acid injections
with glucosamine in patients with knee osteoarthritis
Date of Defense 2009-06-10
Page Count 60
Keyword
  • Hyaluronic Acid
  • osteoarthritis
  • Glucosamine
  • Abstract Background : The oral administration of Glucosamine and intra-articular (IA) injection of
    Hyaluronic Acid were used to treat osteoarthritis. Several studies supported that clinical pain
    symptoms could be alleviated, and activities of daily life improved after the completion of IA knee
    hyaluronic acid injections. However, the efficacy of oral administration of Glucosamine was
    inconclusive. In Taiwan, the Taiwan's National Health Insurance (NHI) made the strict formulations
    for the both of “oral administration of Glucosamine “and “IA knee hyaluronic acid injections.” But,
    there were no evidence to prove that whether the combined treatments from both oral
    administration of Glucosamine and IA knee hyaluronic acid injections were more effective than the
    treatment with the IA knee hyaluronic acid injections alone.
    Objectives : The porpose of this study was to examine whether the effects of treatment combined
    with both “oral administration of Glucosamine and IA knee hyaluronic acid injections” on clinical
    pain symptoms and activities of daily living were better than “IA knee hyaluronic acid injections”
    alone.
    Methods : We randomly assigned 60 patients with symptomatic knee osteoarthritis, at the
    department of Orthopedics, Kaohsiung Municipal Union Hospital, between 2008 and 2009, to
    receive oral administration of Glucosamine and IA knee hyaluronic acid injections or oral
    administration of Placebo and IA knee hyaluronic acid injections. In this study, clinical pain
    symptoms, and activities of daily living were assessed by using Lequesne's Index, visual analogue
    scale index, Berg Balance Test, and Biodex Balance Test before and after the treatment in 60
    patients with the knee OA.
    Result : The mean age was 66.6 years, and 70 percent were woman. There was a significant
    efficacy before and after treatments both in the treatment group(p<0.001) and the placebo control
    group(p<0.001). In the other hand, there was not the statistical significance in the efficacy between
    the treatment group and the control group(p=0.869).
    Conclusion : The combined treatment with both oral administration of Glucosamine and IA knee
    hyaluronic acid injections was not significantly better than the IA knee hyaluronic acid injections
    alone in reducing knee pain or promoting the function of daily life.
    Advisory Committee
  • Meng-Chiao Lin - chair
  • Ying-Chun Li - co-chair
  • Shu-Chuan Jennifer Yeh - advisor
  • Files
  • etd-0615109-173914.pdf
  • indicate access worldwide
    Date of Submission 2009-06-15

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