Title page for etd-0613116-155436


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URN etd-0613116-155436
Author Chia-chi Peng
Author's Email Address No Public.
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Department Marine Biotechnology and Resources
Year 2015
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Studies on the Secondary Metabolites and Their Biological Activities from the Formosan Soft Coral Sarcophyton cherbonnieri
Date of Defense 2016-06-16
Page Count 15
Keyword
  • cytotoxic activity
  • secondary metabolites
  • cembranoid
  • Sarcophyton cherbonnieri
  • Abstract Marine invertebrates have been found to be a rich source of bioactive secondary metabolites. In order to discover bioactive compounds, we have studied the chemical constituents from the organic extracts of Formosan soft corals, Sarcophyton cherbonnieri. The study on the chemical constituents of the ethyl acetate extract of Sarcophyton cherbonnieri has led to the isolation of sixteen natural cembrane-type diterpenoids, compounds 1–16, including fifteen new compounds, cherbonolide A-N (2–15) and bischerbolide peroxide (16), along with one known compound 1, isosarcophine.
     The structures of these compounds 1-16 were established by detailed spectroscopic data analysis comprising IR, UV, specific optical rotations, circular dichroism, MS, 1D NMR, 2D NMR, and by comparison of the physical and spectral data with those of the related known compounds. The absolute configuration of 2 and 4 were determined using a modified Mosher’s method and the structures of 3, 6 and 10 were further established by organic methods. 15 is a rare cembranoid of 12, 17-ether linkage skeleton. 16 is discovered to be the first skeleton that two cembranoid were connected by peroxide group.
     The cytotoxicity of compounds 1–16 against the A549 (human lung adenocarcinoma), DLD-1 (human colorectal adenocarcinoma), and HuCCT-1 (human intrahepatic cholangiocarcinoma) tumor cell lines was determined. The results didn’t show cytotoxic activity.
    Advisory Committee
  • Yang-Chang Wu - chair
  • Ping-Jyun Sung - co-chair
  • Fang-Rong Chang - co-chair
  • Jyh-Horng Sheu - advisor
  • Files
  • etd-0613116-155436.pdf
  • Indicate in-campus at 5 year and off-campus access at 5 year.
    Date of Submission 2016-07-19

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