Title page for etd-0612117-153003


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URN etd-0612117-153003
Author Yen-You Lin
Author's Email Address No Public.
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Department Marine Biotechnology and Resources
Year 2016
Semester 2
Degree Ph.D.
Type of Document
Language English
Title The effects of anti-inflammatory marine-derived compounds on arthritic rats
Date of Defense 2017-04-21
Page Count 269
Keyword
  • osteoclast
  • arthritis
  • coral
  • crinoid
  • inflammation
  • Abstract The sea has long been considered an important resource for the development of novel drugs aimed at treating human diseases, and there are eight marine drugs discovery from over 24,000 marine-derived compounds currently used in clinical medicine. Meanwhile, many types of research have indicated that inflammation plays important roles in human diseases such as cancer, neurodegenerative diseases, and immune diseases. Therefore, anti-inflammatory activity is an essential bioactivity to screen for when seeking to develop marine compounds. Rheumatoid arthritis (RA) is an autoimmune-mediated inflammatory disease which is characterized by synovial inflammation, as well as joint damage, cartilage destruction, and bone erosion with osteoclast activation. Thus, we screened for the anti-inflammatory or anti-arthritic activity of crinoid- and coral-derived compounds in this study. The results showed that there are 4 crinoid-derived compounds that exhibited anti-inflammatory activity in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. Moreover, we also studied the anti-arthritic effects of excavatolide B (Exc-B) and W2AL5 in vivo studies, both of which have been identified as anti-inflammatory, anti-cancer agents and analgesics in past research studies. We found that both Exc-B and W2AL5 could significantly attenuate the characteristics of RA by improving histopathological features and reducing the expressions of pro-inflammatory and osteoclastic proteins in animal models. We also found that both Exc-B and W2AL5 exhibited anti-osteoclastogenesis activity via their respective reductions of the activity of the mitogen-activated protein kinases (MAPK) pathway and the expressions of osteoclastic-related proteins. Hence, these findings strongly suggest that marine compounds offer a potential strategy for treating inflammatory diseases and could also provide a useful therapeutic strategy for the treatment of arthritis.
    Advisory Committee
  • Ping-Jyun Sung - chair
  • Shu-Fen Wu - co-chair
  • Yen-Hsuan Jean - co-chair
  • Jui-Hsin Su - co-chair
  • Chun-Lin Chen - co-chair
  • Chia-Hung Yen - co-chair
  • Zhi-Hong Wen - advisor
  • Files
  • etd-0612117-153003.pdf
  • Indicate in-campus at 99 year and off-campus access at 99 year.
    Date of Submission 2017-07-12

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