Title page for etd-0530114-225016


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URN etd-0530114-225016
Author Ching-Ya Chen
Author's Email Address No Public.
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Department Computer Science and Engineering
Year 2013
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title The Detection of GABA, Lactate and Valine in Human Brain using MEGA-PRESS Spectral Editing Technique.
Date of Defense 2014-06-30
Page Count 68
Keyword
  • MEGA-PRESS
  • VeSPA
  • MRS
  • coupled spin systems
  • spectrum editing
  • Abstract GABA (γ-aminobutyric acid) is one of amino acid neurotransmitter which plays an important role in the central nervous system (CNS). A change in GABA concentration is considered to be associated with some neurological disorders, such as: Epilepsy, Alzheimer's disease. Magnetic resonance spectroscopy is a tool that enables measurement of metabolic concentrations in vivo. One of the most commonly employed pulse sequences is PRESS (Point-RESolved Spectroscopy sequence). However, the signal of GABA is easily obstructed by signals of other metabolites. PRESS does not provide sufficiently high resolution in the clinical experiments. In recent years, in order to obtain signal from GABA, MEGA-PRESS has become popular in the detection of GABA.
    MEGA-PRESS spectral editing technique is based on the original PRESS sequence along with two frequency-selective 〖180〗^° pulses to blend the signal of J-coupled metabolites. These edited J-coupled resonances can be enhanced by spectral subtraction removing non J-coupled resonances. Our results show that under conventional 3T magnetic field, MEGA-PRESS can be applied to detect signals of J-coupled metabolites, such as GABA, Lactate and Valine.
    Key words: MRS, spectrum editing, coupled spin systems, MEGA-PRESS, VeSPA
    Advisory Committee
  • Hsiao-Wen Chung - chair
  • Tzu-Chao Chuang - co-chair
  • Shang-Yuei Tsai - co-chair
  • Ping-Hong Lai - co-chair
  • Cheng-Wen Ko - advisor
  • Files
  • etd-0530114-225016.pdf
  • Indicate in-campus at 5 year and off-campus access at 5 year.
    Date of Submission 2014-07-01

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