Title page for etd-0121113-112358


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URN etd-0121113-112358
Author Yi-Shin Lin
Author's Email Address No Public.
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Department Marine Biotechnology and Resources
Year 2012
Semester 1
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Establishment of epilepsy-like model in zebrafish
Date of Defense 2012-12-26
Page Count 88
Keyword
  • behavior
  • antiepileptic drugs
  • epilepsy-like model
  • zebrafish
  • epilepsy
  • Abstract To date, some mammalian animal models were established for screening new drugs and investigating the mechanisms of epilepsy. However, there were several limits in mammalian model, such as higher costs in breeding, nursing, bigger size and higher dosage. Recently, zebrafish (Danio rerio) had become a potential model animal, which has some advatnges, such as lower dosage to mammalian, a short reproductive cycle with massive amount of offspring, and its gene homologous to human for 70-80%. Moreover, zebrafish, with a fully developed nervous system, would be a suitable model animal for exploring and analyzing of human CNS disease. Our results revealed that the epilepsy-like zebrafish model could be attenuated by clinical drugs. Therefore, we intended to use this model for a rapid in vivo screening of threaprutic compounds in the future.
    Advisory Committee
  • Hui-Min Wang - chair
  • Wu-Fu Chen - co-chair
  • Zhi-Hong Wen - advisor
  • Files
  • etd-0121113-112358.pdf
  • Indicate in-campus at 99 year and off-campus access at 99 year.
    Date of Submission 2013-01-21

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