Title page for etd-0114108-145407


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URN etd-0114108-145407
Author CHING-LI LO
Author's Email Address ball5424@yahoo.com.tw
Statistics This thesis had been viewed 5571 times. Download 1366 times.
Department Marine Biotechnology and Resources
Year 2007
Semester 1
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Studies on the Natural Products of the Formosan Soft Corals Sinularia sp. and Sinularia lochmodes
Date of Defense 2007-07-20
Page Count 152
Keyword
  • Sinularia sp.
  • Sinularia lochmodes
  • Abstract The chemical constituents of organic extracts of the Formosan soft
    corals Sinularia sp. and Sinularia lochmodes were studied. Investigation on Sinularia sp. has led to the isolation of eight compounds (1-8), including four new compounds, 1α,3β-dihydroxy-24S-methylcholesta-5,9-diene (1), 1α,3β-dihydroxy-24-methylencholesta-5-ene (2), 1α,3β-dihydroxy
    -24S-methylcholesta-5-ene (3), sinularioperoxide E (4), and four known compounds, 7-isopropenyl-1,4a-dimethyl-decahydro-naphthalen-1-ol (5), β-dictyopterol (6), N-(4-hydroxyphenethyl)-3-methyldodecanamide (7), (Z)-N-[2-(4-hydroxyphenyl)ethyl]-3-methyldodec-2-enamide (8). Also, investigation on the chemical constituent of Sinularia lochmodes has led to the isolation of two new compounds, lochmolin A (9) and lochmolin B (10). The structures of 1–10 were elucidated by spectroscopic evidences
    (1D NMR, 2D NMR, IR, and MS). The activity of compounds 2-6 to inhibit the pro-inflammatory iNOS and COX-2 protein expression of LPS-stimulated
    RAW-264.7 macrophage cells have been estimated.
    Advisory Committee
  • none - chair
  • none - co-chair
  • Jyh-Horng Sheu - advisor
  • Files
  • etd-0114108-145407.pdf
  • indicate access worldwide
    Date of Submission 2008-01-14

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