Title page for etd-0021114-110357


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URN etd-0021114-110357
Author Tzu-hui Yu
Author's Email Address No Public.
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Department Biological Sciences
Year 2013
Semester 1
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Microsomal epoxide hydrolase and Glutathione-S- transferase Gene Polymorphism in man with Chronic Obstructive Pulmonary Disease
Date of Defense 2014-01-14
Page Count 53
Keyword
  • glutathione s-transferase
  • microsomal epoxide hydrolase
  • restriction fragment length polymorphism
  • chronic obstructive pulmonary disease
  • deoxyribonucleic acid
  • Abstract Genetic association studies have implicated a variety of gene in COPD pathogenesis, such as GST (Glutathione-S-transferase) and mEPH (microsomal epoxide hydrolase) for COPD patients in Taiwan. The current problem in studies of genetic polymorphism of GST and mEPH in COPD is the different results from various studies. These may occur because of the phenotype definitions, sex or ethnic difference. The aim of this study is to confirm and advance our knowledge of the role of this genetic variation in COPD.
    The genotypes of 149 patients with COPD and 125 control subjects were evaluated by polymerase chain reaction and followed by restriction fragment length polymorphism analysis of the mEPH and GST (GST-P1 and M1) genes. All subjects were men over 40 years-old who smoked.
    The mEPH 113 (His113/His113) mutant homozygote had a strong association with COPD (OR 1.84, 95%CI: 1.03-3.27), patients with the His113 mutant homozygote was increased in COPD patients as compared with the control group (43.6% [65/149] vs. 30.4% [38/125]; p= 0.024). No significant difference of GST genetic variation between COPD and control group was noted.
    mEPH 113 mutant homozygote but not GST gene polymorphism was a significant risk factor in susceptibility to COPD in male smokers.
    Advisory Committee
  • Ching-Mei Hsu - chair
  • Chiung-Zuei Chen - co-chair
  • Ming-Hong Tai - advisor
  • Files
  • etd-0021114-110357.pdf
  • Indicate in-campus at 0 year and off-campus access at 1 year.
    Date of Submission 2014-01-21

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