Title page for etd-0004114-171704


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URN etd-0004114-171704
Author Ching-tong Chen
Author's Email Address No Public.
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Department Biological Sciences
Year 2013
Semester 1
Degree Ph.D.
Type of Document
Language zh-TW.Big5 Chinese
Title Studies on the Chemical Constituents from Aquilaria sinensis Grown in Taiwan
Date of Defense 2013-12-20
Page Count 126
Keyword
  • flavonoids
  • Aquilaria sinensis
  • β- sitostenone
  • methylparaben
  • 5-hydroxy-7,3′,4′-trimethoxyflavone
  • 5-hydroxy-7,4′-dimethoxyflavone
  • Abstract Organisms in the genus Aquilaria (Thymelaeaceae) are widely distributed in Asia. Previous phytochemical investigation on Chinese agarwood revealed characteristic sesquiterpenes and chromone derivatives, but the chemical constituents in each part of the agarwood is not clear. The chemical constituents in the wood and bark of Aquilaria sinensis were separated with column chromatography. Twelve compounds, including four flavonoids, 5-hydroxy-7,4′-dimethoxyflavone, 5-hydroxy-7,3′,4′-trimethoxyflavone, 5,3′-dihydroxy-7,4′-dimethoxyflavone and 5,4′-dihydroxy-7,3′-dimethoxyflavone , three benzenoids, vanillic acid , p-hydroxybenzoic acid , and syringic acid , one quinol, 4-acetonyl -3,5-dimethoxy-p-quinol, two amides, N-trans-feruloyltyramine and N-cis-feruloyltyramine , one lignan, (+)-syringaresinol and one steroid, β-sitostenone were isolated from the wood of A. sinensis. Eight compounds, including five flavonoids, 5-hydroxy-7,4′-dimethoxyflavone, 5,4′-dihydroxy-7-methoxyflavone , 5-hydroxy -7,3′,4′-trimethoxyflavone , 5,3′-dihydroxy-7,4′-dimethoxyflavone and 5,4′-dihydroxy-7,3′-dimethoxyflavone , one benzenoid, methylparaben , one lignan, (+)-syringaresinol and one steroid, β-sitosterol were isolated from the bark of A. sinensis. All of these compounds were obtained for the first time from this plant. The anti-cancer activities of 5-hydroxy-7,4′-dimethoxyflavone, 5,4′-dihydroxy-7-methoxyflavone, 5-hydroxy-7,3′,4′-trimethoxyflavone, 5,3′-dihydroxy-7,4′-dimethoxyflavone on melanoma were examined. Results indicated that the anti-cancer effects of these four compounds increase with the increasing doses.
    Advisory Committee
  • Soong Yu Kuo - chair
  • Sin Dan Lee - co-chair
  • Hui-Min, Wang - co-chair
  • David Chao - advisor
  • Chung Yi Chen - advisor
  • Files
  • etd-0004114-171704.pdf
  • Indicate in-campus at 5 year and off-campus access at 99 year.
    Date of Submission 2014-01-06

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